Thrombopoietin (TPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone that is the key regulator of megakaryopoiesis and thrombopoiesis. TPO is constitutively expressed by liver and bone marrow cells and is cleared from circulation by binding to the cMPL receptor. TPO stimulates bone marrow progenitor cells to proliferate and mature into megakaryocytes that produce platelets, which play critical roles in hemostasis. Circulating TPO levels may be useful in differentiating thrombocytopenias caused by peripheral destruction from those due to thrombopoietic failure; in the former, levels are depressed while in the latter levels are elevated. Elevated TPO levels may also serve as a biomarker for vascular damage and coronary angina. TPO may enhance platelet aggregation and platelet/monocyte interactions.


TPO Singleplex Products

Our TPO immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of TPO. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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TPO Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.


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