MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Thrombopoietin (TPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone that is the key regulator of megakaryopoiesis and thrombopoiesis. TPO is constitutively expressed by liver and bone marrow cells and is cleared from circulation by binding to the cMPL receptor. TPO stimulates bone marrow progenitor cells to proliferate and mature into megakaryocytes that produce platelets, which play critical roles in hemostasis. Circulating TPO levels may be useful in differentiating thrombocytopenias caused by peripheral destruction from those due to thrombopoietic failure; in the former, levels are depressed while in the latter levels are elevated. Elevated TPO levels may also serve as a biomarker for vascular damage and coronary angina. TPO may enhance platelet aggregation and platelet/monocyte interactions. The U-PLEX NHP TPO Assay provides the components for the quantitative determination of both natural and recombinant TPO in Cynomolgus monkey and Rhesus monkey serum, plasma, and cell culture supernatants.

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