TNF-α

Tumor Necrosis Factor-α (TNF-α), also known as tumor necrosis factor ligand superfamily member 2 (Tnfsf2) and cachectin, is a transmembrane protein that oligomerizes intracellularly to form a non-covalent homotrimer. The membrane-bound soluble portion of the homotrimer is cleaved by TACE/ADAM17 to form TNF-α. The homotrimer binds to the receptors, TNF RI and TNF RII, both of which are also expressed as homotrimers. TNF-α is mainly secreted by macrophages and a variety of other cell types under pathogenic conditions. Upon receptor binding, TNF-α has been shown to trigger diverse cell signaling pathways including apoptosis, proliferation, differentiation, chemoattraction, hypothalamic regulation, and cytokine production. TNF-α also stimulates IL-1 and induces cachexia, which causes fever. The intracellular form of TNF-α induces IL-12 production in dendritic cells. TNF-α can induce sepsis and inflammation as well as inhibit tumorigenesis and viral replication.

 

TNF-α Singleplex Products

Our TNF-α immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of TNF-α. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

View All
TNF-α Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

View All
Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • TNF-α - Non-human primate
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters