TIMP-1

Tissue Inhibitor of MetalloProteinases-1 (TIMP-1, EPPA, EPO, HCI, CLGI, TIMP) is a glycoprotein and a natural inhibitor of matrix metalloproteases (MMPs and ADAMs). It is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones and is important in prenatal development. TIMP-1 is widely present in many tissues and cell types. Overexpression of TIMP-1 correlates with aggressive pathogenesis of a variety of tumors. It has also been shown that total TIMP-1 plasma levels can be related to cardiovascular risk factors influencing cardiovascular remodeling via extracellular matrix degradation.

 

TIMP-1 Singleplex Products

Our TIMP-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of TIMP-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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TIMP-1 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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