R-PLEX Human TIMP-1 Antibody Set

R-PLEX Human TIMP-1 Antibody Set Overview
The R-PLEX Human TIMP-1 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of TIMP-1 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human TIMP-1 Antibody Set Features
  • Measures human TIMP-1 in plasma
  • Dynamic range: 41 - 50,000 pg/mL
  • Median LLOD: 41 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human TIMP-1 Antibody Set was assessed and representative data is presented below.

Figure 1. R-PLEX Human TIMP-1 Antibody Set Calibration Curve
Calibration curve for R-PLEX Human TIMP-1 Antibody Set
TIMP-1 Analyte

Description - Tissue Inhibitor of MetalloProteinases-1 (TIMP-1, EPPA, EPO, HCI, CLGI, TIMP) is a glycoprotein and a natural inhibitor of matrix metalloproteinases (MMPs and ADAMs). It is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Its expression is highly inducible in response to many cytokines and hormones and is important in prenatal development. Overexpression of TIMP-1 correlates with aggressive pathogenesis of a variety of tumors. It has also been shown that total TIMP-1 plasma levels can be related to cardiovascular risk factors influencing cardiovascular remodeling via extracellular matrix degradation.

Disease Research Area - Cancer, Metastasis, Fetal Development

Application Area - Angiogenesis & vascular, Oncology & Cancer, Cardiovascular

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5 plate size
50 plate size
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