SAA

Serum Amyloid A (SAA) proteins are multifunctional, acute-phase proteins produced by hepatocytes in response to proinflammatory cytokines. SAA has been linked to functions related to inflammation, pathogen defense, HDL metabolism, and cholesterol transport. Thereby, SAA has been implicated in several pathological conditions including atherosclerosis, rheumatoid arthritis, Alzheimer’s disease, and cancer. SAA circulates at trace levels (1-5 mg/mL) under normal conditions but levels can dramatically increase 1000-fold (500-1000 mg/mL) within 4-6 hours after inflammatory stimuli such as infection, tissue injury, or trauma. Measuring SAA levels in these patients may be a useful indicator of degree of inflammation and response to therapy.

 

SAA Singleplex Products

Our SAA immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of SAA. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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