N-terminal pro-brain (or B-type) natriuretic peptide (NT-proBNP) is produced predominately by the cardiac ventricular myocytes. NT-proBNP is released in response to volume expansion and filling pressure and is involved in maintaining intravascular volume homeostasis. In rats, the generation of NT-proBNP initially starts with the formation of an 121 amino acid (aa) prepro-BNP containing a 26 aa signal sequence. Proteolytic cleavage of the signal peptide releases pro-BNP, which contains 95 aa residues. Further proteolysis of pro-BNP generates a biologically inactive 50 aa NT-proBNP and an active 45 aa BNP molecule. Elevated plasma levels of BNP and NT-proBNP have been observed at times of cardiac stress and damage. 


NT-proBNP Singleplex Products

Our NT-proBNP immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of NT-proBNP. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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