R-PLEX Human NT-proBNP Antibody Set

R-PLEX Human NT-proBNP Antibody Set Overview
The R-PLEX Human NT-proBNP Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of NT-proBNP in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human NT-proBNP Antibody Set Features
  • Measures human NT-proBNP in serum and plasma
  • Dynamic range: 0.30 - 500 pg/mL
  • Median LLOD: 0.30 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human NT-proBNP Antibody Set was assessed and representative data are presented below.

Figure 1. R-PLEX Human NT-proBNP Antibody Set Calibration Curve
Calibration Curve for R-PLEX Human NT-proBNP Antibody Set
NT-proBNP Analyte

Description - N-Terminal pro-B-type Natriuretic Peptide (NT-proBNP, NPPB, natriuretic peptide B, BNP) is produced by the cardiac ventricular myocytes. NT-proBNP is released in response to volume expansion and filling pressure and is involved in maintaining intravascular volume homeostasis. Proteolytic cleavage of the signal peptide releases pro-BNP. Further proteolysis of pro-BNP generates an active 45 aa BNP molecule. Elevated plasma levels of BNP and NT-proBNP have been observed at times of cardiac damage, making this a useful tool for cardiovascular research.

Disease Research Area - Cardiovascular Disease

Application Area - Cardiac Biomarkers, Cardiac Injury

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5 plate size
50 plate size
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