MPO

Myeloperoxidase (MPO) is a member of the heme protein superfamily that is abundantly present in azurophilic granules of plymorphonuclear neutrophils. MPO is produced by neutrophils and monocytes in response to leukocyte activation. These phagocytic cells undergo respiratory burst on stimulation. The extra oxygen that is consumed during this process is converted to hydrogen peroxide. MPO released from the azurophilic granules of neutrophils and monocytes react with the hydrogen peroxide to form potent oxidizing complexes. The oxidants of the MPO-H2O2-halide system have potent bactericidal and viricidal activities. Thus, MPO plays an important role in many inflammatory reactions and contributes to innate host responses. MPO and its oxidation products have been found in atherosclerotic lesions. High levels of MPO have been demonstrated to predict angiographic coronary artery disease. MPO has been implicated in the oxidative modification of HDL with consequent functional inactivation. Thus MPO is one of the most promising cardiac markers to identify patients with increased risk of cardiovascular events. MPO has also been implicated in the pathogenesis of renal disease, lung injury, multiple sclerosis, Alzheimer’s disease, brain infarction and Parkinson’s disease.

 

MPO Singleplex Products

Our MPO immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MPO. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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