MIP-5

Macrophage inflammatory protein 5 (MIP-5) (CCL15/NCC3/SCYA15) is a C-C chemokine attractant for neutrophils, monocytes, and lymphocytes. MIP-5 is highly expressed in the liver, small intestine, and colon; expressed to a lesser degree in the lungs; and secreted by T and B lymphocytes, NK cells, monocytes, and monocyte-derived dendritic cells. It primarily acts through CCR1, but MIP-5 can also bind CCR3. MIP-5 is implicated in asthma and sarcoidosis, where increased expression is thought to be linked to disease progression and pathogenesis. MIP-5 also shows promise as a potential blood biomarker for Alzheimer’s disease in lieu of cerebrospinal fluid biomarkers, showing decreased monocyte levels and a corresponding increased plasma concentration in diseased and early symptom patients. MIP-5 has also been shown to be involved in atherosclerosis, as its presence stimulates the secretion of matrix metalloprotein-9, which is associated with atherosclerotic plaque destabilization and rupture.

 

MIP-5 Singleplex Products

Our MIP-5 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MIP-5. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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MIP-5 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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