MIP-3β

Macrophage inflammatory protein 3 beta (MIP-3β) (CCL19) is a homeostatic C-C chemokine associated with CCR7, of which CCL21 is also a ligand, expressed and secreted in abundance by stromal cells of the lymph nodes. MIP-3β function is central to chemotactic migration of dendritic cells to the lymph nodes, orientation within the nodes, and activation of T cells once there. MIP-3β’s chemotactic effect on lymphocytes induces a proinflammatory response in organs and areas of non-lymphoid origin that results in de novo formation of lymphoid tissue. This suggests a role in inflammatory disorders that include rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis, evidenced by increased expression and elevated levels of MIP-3β, its receptor CCR7, and related chemokine, CCL21. Moreover, MIP-3β is thought to play a role in HIV infection, with MIP-3β serum levels positively correlated with HIV progression. The proposed mechanism of action creates a detrimental pathogenic feedback loop wherein HIV infection increases the presence of MIP-3β and CCL21, leading to inappropriate inflammation that further promotes HIV replication in activated T cells.

 

MIP-3β Singleplex Products

Our MIP-3β immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MIP-3β. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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MIP-3β Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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