MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Macrophage inflammatory protein 3 beta (MIP-3β) (CCL19) is a homeostatic C-C chemokine associated with CCR7, of which CCL21 is also a ligand, expressed and secreted in abundance by stromal cells of the lymph nodes. MIP-3β function is central to chemotactic migration of dendritic cells to the lymph nodes, orientation within the nodes, and activation of T cells once there. MIP-3β’s chemotactic effect on lymphocytes induces a proinflammatory response in organs and areas of non-lymphoid origin that results in de novo formation of lymphoid tissue. This suggests a role in inflammatory disorders that include rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis, evidenced by increased expression and elevated levels of MIP-3β, its receptor CCR7, and related chemokine, CCL21. Moreover, MIP-3β is thought to play a role in HIV infection, with MIP-3β serum levels positively correlated with HIV progression. The proposed mechanism of action creates a detrimental pathogenic feedback loop wherein HIV infection increases the presence of MIP-3β and CCL21, leading to inappropriate inflammation that further promotes HIV replication in activated T cells. The U-PLEX NHP MIP-3β Assay provides the components for the quantitative determination of both natural and recombinant macrophage inflammatory protein 3 beta (MIP-3β) in Cynomolgus monkey and Rhesus monkey serum, plasma, and cell culture supernatants.

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