MCP-2

Monocyte chemotactic protein-2 (MCP-2, CCL8) is a chemokine that utilizes multiple cellular receptors (CCR1, CCR2B, and CCR5) to attract and activate several different immune cells such as mast cells, eosinophils, and basophils, all of which are involved in allergic responses, plus monocytes, CD4+ and CD8+ T-cells, and NK cells. MCP-2 is often expressed by stromal tissues that have been exposed to viruses, bacteria, and fungi. MCP-2 recruits immature monocytes to these inflamed states aiding their maturation into antigen presentation or dendritic cells. This supports further T-cell activation and provides the switch from resolving to persistent inflammation and infection. It is through these same functional roles that MCP-2 may be used to enhance adoptive T-cell therapy for treatment of cancer and chronic infections. In addition, MCP-2 is a potent inhibitor of HIV-1 binding to CD4+ T-cells through its high-affinity binding to the CCR5 receptor, a major co-receptor for HIV-1 entry and replication into cells. Production of chemical or biological biosimilars to MCP-2 and related chemokines is an emerging area of therapeutic development to combat several chronic inflammatory diseases.

 

MCP-2 Singleplex Products

Our MCP-2 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MCP-2. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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MCP-2 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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