M-CSF

Macrophage colony-stimulating factor (M-CSF), also called CSF-1 (colony-stimulating factor 1), is a hematopoietin that regulates the proliferation, survival and differentiation of mononuclear phagocytes, tissue macrophages and osteoclasts. All forms of M-CSF are highly glycosylated, with the secreted forms more glycosylated than the cell surface forms. It is produced by several cell types including fibroblasts, stromal cells, astrocytes, osteoblasts, activated macrophages, B-cells, T-cells and epithelial cells of the endometrium. Certain neoplastic cell lines, such as leukemic, pancreatic and lymphoma cell lines synthesize M-CSF. M-CSF is produced in high levels by uterine epithelial cells during pregnancy. High levels of M-CSF are observed in patients with certain neoplastic and reproductive disorders. Liver disease, hepatic injury, haemophagocytic syndrome, thalassemia and amyloidosis are also associated with increased M-CSF levels. M-CSF is elevated in ischemic heart disease. Circulating M-CSF levels has been suggested as a marker for ovarian, breast and endometrial cancers. M-CSF has also been associated with the pathogenesis of atherosclerosis.

 

M-CSF Singleplex Products

Our M-CSF immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of M-CSF. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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M-CSF Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • M-CSF Mouse - Mouse
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