Leucine rich repeat kinase 2 (LRRK2, PARK8, RIPK7, ROCO2, AURA17, dardarin) is a member of the leucine-rich repeat kinase family, and is a protein with multiple domains including: kinase, leucine rich repeat, RAS, GTPase and WD40. Variants and mutants of this gene are associated with increased risk of Parkinson's disease (PD). LRRK2 is extensively phosphorylated both in cytosol and mitochondrial membranes. The various phosphorylations are being studied with regard to their roles in PD. Genomic studies indicate LRRK2 variants also increase the risk of Crohn's disease.


LRRK2 Singleplex Products

Our LRRK2 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of LRRK2. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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