IRS-1

Insulin receptor substrate 1 (IRS-1) is a phosphoprotein and a member of the insulin receptor substrate family of proteins. These are cytoplasmic adaptor proteins that propagate a signal from an activated cell surface receptor. IRSs are non-enzymatic and do not directly phosphorylate any other proteins. Their ability to effect downstream signaling is as adaptor proteins which recruit other proteins into larger signaling complexes. IRS-1 is a signaling intermediate between the insulin receptor (IR) and the insulin like growth factor-1 receptor (IGF-1R) and the downstream PI3K and MAPK signaling cascades. Upon ligand stimulation and autophosphorylation of the IR and IGF-1R, IRS-1 binds to these activated receptors (and receptor hybrids) through its SH2 containing domains, becomes phosphorylated on multiple tyrosine residues, and is able to activate and recruit downstream signaling partners in the PI3K/AKT and ERK/MAPK signaling pathways. The IRS family of proteins is highly studied due to their roles in the very early phases of cancer as well as metastatic progression, and these proteins are seen to have potential both as therapeutic targets of drug development and diagnostic predictors of therapeutic effectiveness, due to their role in drug resistance.

 

IRS-1 Singleplex Products

Our IRS-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IRS-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IRS-1 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • IRS-1 (total) - Human
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