IL-6R

Interleukin-6 Receptor (IL-6R, IL6Q, gp80, CD126, IL6RA, IL6RQ) is the receptor for a multi-functional cytokine that is produced by a variety of cell types. The functional receptor consists of two distinct membrane bound subunits, an 80 kDa alpha subunit (IL-6R) and a 130 kDa signal-transducing beta subunit (gp130). IL-6R is expressed by hepatocytes, monocytes, neutrophils, T cells, and B cells. In contrast, gp130 is expressed by most organs, including heart, kidney, spleen, liver, lung, placenta, and brain. IL-6 interacts with IL-6R with low affinity. This heterodimer binds to gp130 to form the high affinity signal transducing complex. Clinically significant levels of soluble IL-6R have been reported in the progressive stages of rheumatoid arthritis. Elevated concentrations of IL-6 and soluble IL-6R have been implicated in chronic inflammatory conditions such as Crohn’s disease and ulcerative colitis, as well as in pathological conditions including multiple myeloma patients. It has been suggested that soluble IL-6R may be elevated in disease conditions involving high levels of IL-6.

 

IL-6R Singleplex Products

Our IL-6R immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-6R. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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