IL-27

Interleukin-27 (IL-27), a heterodimeric cytokine and a relatively new member of the IL-6/IL-12 family, plays an important role in the regulation of TH1 responses. IL-27 consists of two subunits, an EBV-transformed gene 3 (EBI3) subunit and a p28 cytokine subunit. IL-27 activity is mediated by binding to its receptor, IL-27R, comprised of WSX-1 and gp130. Several immune cells co-express both subunits of the IL-27 receptor. IL-27 is expressed by antigen-presenting cells upon antigen activation. IL-27 potently induces the proliferation of naive T cells, and synergistically with IL-12 stimulates the production of IFN-γ by naive CD4+ T cells. Studies indicate that IL-27 has strong antitumor and antimetastatic abilities. IL-27 also plays a role in the induction of several antiangiogenic chemokines, such as IP-10 and MIG. These factors make IL-27 an attractive candidate for cancer immunotherapy.

 

IL-27 Singleplex Products

Our IL-27 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-27. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-27 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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