IL-17B

The Interleukin-17 (IL-17) cytokines are emerging as key regulators of initiation and maintenance of the proinflammatory immune response. The family consists of six related molecules: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F. These molecules have a molecular mass of 20–30 kDa and share 20–50% homology to IL-17A. IL-17B is expressed in normal pancreas, small intestine, testis, and stomach. In contrast to other family members, IL-17B stimulates significant induction of TNF-α and IL-1β in monocytes but limits production of IL-6, at least in vitro. In addition, IL-17B is antiangiogenic as it can inhibit endothelial cell migration and tubule formation with little effect on endothelial cell growth. This is opposite to the role of IL-17A which promotes these processes. Therefore, tissue-specific proinflammatory or inhibitory cytokine functions may be regulated by localized concentrations of different IL-17 family members based on their expression patterns and target cell populations.

 

IL-17B Singleplex Products

Our IL-17B immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-17B. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-17B Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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