IL-17A

Interleukin-17 (IL-17) cytokines are emerging as key regulators of initiation and maintenance of the proinflammatory immune response. The family consists of six related molecules: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F. These molecules have a molecular mass of 20–30 kDa and share 20–50% homology to IL-17A. In general, IL-17 induces several pro-inflammatory molecules such as IL-6, IL-8, GM-CSF, IL-1, TNF-α, and MCP-1 from different cell types including fibroblasts, endothelial cells, epithelial cells, and tissue-specific macrophages. Thus, it makes sense that these cytokines are linked to inflammatory diseases, including rheumatoid arthritis, asthma, lupus, allograft rejection, and tumorigenicity. However, differences in expression patterns and production levels appear to give specificity of action and role to each of the IL-17 family members.

 

IL-17A Singleplex Products

Our IL-17A immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-17A. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-17A Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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