ICAM-1

Intercellular adhesion molecule-1 (ICAM-1/CD54) is a nearly ubiquitous transmembrane glycoprotein that plays a key role in leukocyte migration and activation. ICAM-1 binds to leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). At sites of inflammation, ICAM-1 is upregulated on endothelial and epithelial cells where it mediates the adhesion and prolongs antigen presentation by dendritic cells and promotes T-cell proliferation and cytokine release. ICAM-1 activation also participates in angiogenesis, wound healing, and bone metabolism. Soluble forms of monomeric and dimeric ICAM-1 (sICAM-1) can be generated via proteolytic cleavage. It has been reported in serum, cerebrospinal fluid, urine, and bronchoalveolar lavage fluid. Elevated levels of sICAM-1 in these fluids are associated with cardiovascular disease (can be an indicator of vascular endothelial cell activation or damage), type 2 diabetes, organ transplant dysfunction, and certain malignancies.

 

ICAM-1 Singleplex Products

Our ICAM-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of ICAM-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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