V-PLEX Plus Human ICAM-1 Kit


Intercellular adhesion molecule 1 (ICAM-1/CD54) is a nearly ubiquitous transmembrane glycoprotein that plays a key role in leukocyte migration and activation. ICAM-1 binds to leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). At sites of inflammation, ICAM-1 is upregulated on endothelial and epithelial cells, where it mediates the adhesion and prolongs antigen presentation by dendritic cells and promotes T-cell proliferation and cytokine release. ICAM-1 activation also participates in angiogenesis, wound healing, and bone metabolism. Soluble forms of monomeric and dimeric ICAM-1 can be generated via proteolytic cleavage. It has been reported in serum, cerebral spinal fluid, urine, and bronchoalveolar lavage fluid. Elevated levels of ICAM-1 in these fluids are associated with cardiovascular disease (as an indicator of vascular endothelial cell activation or damage), type 2 diabetes, organ transplant dysfunction, and certain malignancies. The Human ICAM-1 Kit provides assay-specific components for the quantitative determination of ICAM-1 in human serum, plasma, cell culture supernatants, cerebral spinal fluid, and urine.

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25 plates
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