COVID-19/SARS-CoV-2 Research Applications

COVID-19

 

MSD is committed to providing our customers with products to advance COVID-19 research. Based on recent reports, patients infected by SARS-CoV-2 show elevated levels of inflammatory cytokines that could lead to cytokine release syndrome or "cytokine storm." We offer multiplex assays to measure key biomarkers that are involved in many inflammatory pathways.

MSD is offering pre-configured panels and individual assays for COVID-19 studies based on current recommendations from key opinion leaders and the available literature. You can also configure other panels from our full menu. Helpful references include:

  1. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Lancet. 2020 Feb 15;395(10223):497-506.
  2. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Channappanavar R, Perlman S. Semin Immunopathol. 2017 Jul;39(5):529-539.
  3. Coronavirus infections and immune responses. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, Pan P, Wang W, Hu D, Liu X, Zhang Q, Wu J. J Med Virol. 2020 Apr;92(4):424-432.
  4. Handbook of COVID-19 Prevention and Treatment. First Affiliated Hospital of Zhejiang University.

  5. For Research Use Only. Not for use in diagnostic procedures.

     


    V-PLEX Panels Catalog Number Analytes
    V-PLEX Viral Panel 1 Human Kit K15345D IL-1β, IL-6, IL-8, TNF-α
    V-PLEX Viral Panel 2 Human Kit K15346D IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α
    V-PLEX Viral Panel 3 Human Kit K15347D IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-α
    V-PLEX Proinflammatory Panel 1 Human Kit K15049D IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α
    V-PLEX Vascular Injury Panel 2 Human Kit K15198D CRP, ICAM-1, SAA, VCAM-1
    V-PLEX Human Biomarker 54-Plex Kit K15248D CRP, Eotaxin, Eotaxin-3, FGF (basic), VEGFR-1/Flt-1, GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-1RA, IL-21, IL-22, IL-23, IL-27, IL-31, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, MIP-3α, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, TSLP, VCAM-1, VEGF-A, VEGF-C, VEGF-D
    V-PLEX Viral Panel 1 NHP Kit K15348D IL-1β, IL-6, IL-8
    V-PLEX Viral Panel 2 NHP Kit K15349D IFN-γ, IL-1β, IL-6, IL-8, IL-10
    V-PLEX Viral Panel 3 NHP Kit K15350D IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10
    V-PLEX Proinflammatory Panel 1 NHP Kit K15056D IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10

    U-PLEX Combos Catalog Number Analytes
    U-PLEX Viral Combo 1 Human K15343K G-CSF, GM-CSF, IFN-α2a, IFN-β, IFN-γ, IL-1RA, IL-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP1, MIP-1α, TNF-α, VEGF-A
    U-PLEX Cytokine Combo 1 Human K15045K GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A
    U-PLEX Viral Combo 1 NHP K15344K G-CSF, GM-CSF, IFN-α2a, IFN-γ, IL-1RA, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP1, MIP-1α, TNF-α, VEGF-A
    U-PLEX Cytokine Combo 1 NHP K15057K GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A

    S-PLEX Assays Catalog Number Analyte
    S-PLEX Human G-CSF Kit K151K3S G-CSF
    S-PLEX Human GM-CSF Kit K151F3S GM-CSF
    S-PLEX Human IL-4 Kit K151A3S IL-4
    S-PLEX Human IL-10 Kit K151Y2S IL-10
    S-PLEX Human TNF-α Kit K151E3S TNF-α

    R-PLEX Antibody Set Catalog Number Analyte
    R-PLEX Human Ferritin Antibody Set F21ADA Ferritin

    SARS-CoV-2 image courtesy of CDC/ Alissa Eckert, MS; Dan Higgins, MAMS