V-PLEX Plus Human IL-23 Kit


V-PLEX Plus Human IL-23 Kit Overview
The V-PLEX Plus Human IL-23 Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Plus Human IL-23 Kit enables the sensitive detection of native IL-23 in multiple sample types including serum, plasma, urine, cell culture supernatants, and PBMCs. To learn more about the advantages of V-PLEX assays click here.
The V-PLEX Plus Human IL-23 assay is available as an individual assay kit as well as in a multiplex combination with other TH17-related analytes in the V-PLEX TH17 Panel 1 (human) Kit (catalog # K15085G, K15085D).
All V-PLEX kits come with coated plates, calibrators, labeled detection antibodies, optimized diluents, a comprehensive product insert, and a certificate of analysis. V-PLEX Plus kits also include controls, wash buffer, and plate seals for added quality and convenience.

V-PLEX Plus Human IL-23 Assay Features

  • Validated to measure human IL-23 in serum, plasma, cell culture supernatants, PBMCs, and urine
  • Dynamic range: 0.274 pg/mL – 3,250 pg/mL
  • LLOQ: 4.60 pg/mL

Typical Data
Calibration curve accuracy and precision for the V-PLEX Plus Human IL-23 assay were assessed and representative data are presented below.

Figure 1. V-PLEX Plus Human IL-23 Calibration Curve
Human IL-23 Calibrator Curve
Figure 2. V-PLEX Plus Human IL-23 Data
Human IL-23 Calibrator Curve Data
IL-23 Analyte

Description - Interleukin-23 (IL-23) is a heterodimeric cytokine that is structurally and functionally related to IL 12. Both share the 40 kDa (p40) subunit of IL-12, and this forms a disulfide link with a 19 kDa (p19) subunit to make the active IL-23 molecule. IL-23 is produced by activated macrophages and dendritic cells in response to certain bacterial and viral pathogens and may play a key role in sustaining inflammatory responses that link innate and adaptive immunity. The main role of IL-23 involves the differentiation of TH17 cells, a novel subset of CD4+ memory T cells, and their stimulation to produce the cytokine, IL-17. IL-23 is a key player in sustaining cellular immunity by promoting the survival and effector cytokine production of Th1 memory cells.

Disease Focus - Rheumatoid arthritis, inflammatory bowel disease, diabetes, and tumor growth.

Application Area - Inflammation, cytokines and chemokines

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25 plates
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