V-PLEX Plus Human IL-21 Kit


V-PLEX Plus Human IL-21 Kit Overview
The V-PLEX Plus Human IL-21 Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Plus Human IL-21 Kit enables the sensitive detection of native IL-21 in multiple sample types including serum, plasma, urine, cell culture supernatants, and PBMCs. To learn more about the advantages of V-PLEX assays click here.
The V-PLEX Plus Human IL-21 assay is available as an individual assay as well as in a multiplex combination with other TH17-related analytes in the V-PLEX TH17 Panel 1 (human) Kit (catalog # K15085G, K15085D).
All V-PLEX kits come with coated plates, calibrators, labeled detection antibodies, optimized diluents, a comprehensive product insert, and a certificate of analysis. V-PLEX Plus kits also include controls, wash buffer, and plate seals for added quality and convenience.

V-PLEX Plus Human IL-21 Assay Features

  • Validated to measure human IL-21 in serum, plasma, cell culture supernatants, PBMCs, and urine
  • Dynamic range: 0.193 pg/mL – 650 pg/mL
  • LLOQ: 1.65 pg/mL

Typical Data
Calibration curve accuracy and precision for the V-PLEX Plus Human IL-21 assay were assessed and representative data are presented below.

Figure 1. V-PLEX Plus Human IL-21 Calibration Curve
Human IL-21 Calibrator Curve
Figure 2. V-PLEX Plus Human IL-21 Data
Human IL-21 Calibrator Curve Data
IL-21 Analyte

Description - Interleukin-21 (IL-21) is a regulatory cytokine thought to play a role in the transition between innate and adaptive immunity. It is produced and secreted by a variety of CD4+ T cells, NK cells, and T follicular helper cells. IL 21 is a regulator in the production and proliferation of B cells, T cells, and NK cells. IL-21 activity is mediated by binding its receptor, IL-21R. IL-21 is a target of novel therapeutic approaches such as the use of IL 21 blockers to prevent inflammation and/or malignancy.

Disease Focus - Inflammatory diseases, including rheumatoid arthritis, collagen-induced arthritis, colitis-associated colon cancer, ulcerative colitis, and Crohn’s disease.

Application Area - Inflammation, cytokines and chemokines

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25 plates
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