V-PLEX Mouse IL-31 Kit


Please note: This V-PLEX kit is currently being redeveloped. In the interim, MSD is offering to fulfill your order with the corresponding product on our U-PLEX platform. We recommend purchase of the  U-PLEX Mouse IL-31 Assay.

V-PLEX Mouse IL-31 Kit Overview
The V-PLEX Mouse IL-31 Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Mouse IL-31 Kit enables the sensitive detection of IL-31 in multiple sample types including serum, plasma, urine, and cell culture supernatant. To learn more about the advantages of V-PLEX assays click here.

The V-PLEX Mouse IL-31 assay is available as an individual assay as well as in a multiplex combination with other Th17-related analytes in the V-PLEX Th17 Panel 1 Mouse Kit (catalog # K15246G, K15246D).

All V-PLEX kits come with coated plates, calibrators, labeled detection antibodies, optimized diluents, a comprehensive product insert, and a certificate of analysis.

V-PLEX Mouse IL-31 Assay Features
  • Validated to measure mouse IL-31 in serum, plasma, urine, and cell culture supernatant
  • Dynamic range: 8.57 – 21,000 pg/mL
  • LLOQ: 22.6 pg/mL

Typical Data
Calibration curve for the V-PLEX Mouse IL-31 Kit was assessed and representative data is presented below.

Figure 1. V-PLEX Mouse IL-31 Kit Calibration Curve
Calibration Curve for V-PLEX Mouse IL-31 Kit
IL-31 Analyte

Description - Mouse IL-31 is expressed primarily by TH2 cells and signals through a heterodimeric receptor consisting of GPL (GP130-like) and OSMRβ (oncostatin M receptor β) though it binds directly to the GPL protein. This receptor is found on keratinocytes and IFNγ-activated monocytes. IL-31 participates in atopic dermatitis and inflammatory bowel disease as a powerful proinflammatory cytokine. IL-31 elevates the expression of EGF, VEGF, and MCP-1, and activates MAPK protein, which induces bronchial inflammation.

Disease Research Area - Autoimmune & Inflammation

Application Area - Cytokines & Chemokines, Inflammatory Injury

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