V-PLEX Human IL-31 Kit


V-PLEX Human IL-31 Kit Overview
The V-PLEX Human IL-31 Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Human IL-31 Kit enables the sensitive detection of native IL-31 in multiple sample types including serum, plasma, urine, cell culture supernatants, and PBMCs. To learn more about the advantages of V-PLEX assays click here.
The V-PLEX Human IL-31 assay is available as an individual assay kit as well as in a multiplex combination with other TH17-related analytes in the V-PLEX TH17 Panel 1 (human) Kit (catalog # K15085G, K15085D).

V-PLEX Human IL-31 Assay Features
  • Validated to measure human IL-31 in serum, plasma, cell culture supernatants, PBMCs, and urine
  • Dynamic range: 0.446 pg/mL – 650 pg/mL
  • LLOQ: 4.22 pg/mL

Typical Data
Calibration curve accuracy and precision for the V-PLEX Human IL-31 assay were assessed and representative data are presented below.

Figure 1. V-PLEX Human IL-31 Calibration Curve
Human IL-31 Calibrator Curve
Figure 2. V-PLEX Human IL-31 Data
Human IL-31 Calibrator Curve Data
IL-31 Analyte

Description - Interleukin-31 (IL-31) is a four-helix bundle cytokine that belongs to the gp130/IL-6 cytokine family. IL-31 is produced by TH2 cells and signals through a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor. Signaling by IL-31 activates the JAK-STAT, RAS/ERK, and PI3K/AKT pathways. IL-31 elevates the expression of EGF, VEGF, and MCP-1, and activates MAPK protein, which induces bronchial inflammation.

Disease Focus - Allergic skin conditions such as atopic dermatitis, airway hypersensitivity, and irritable bowel disease.

Application Area - Inflammation, cytokines and chemokines

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1 plate
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25 plates
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