U-PLEX Human MIP-3α Assay


MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Macrophage inflammatory protein 3 alpha (MIP-3α) (LARC/CCL20) is a C-C chemokine with inflammatory and homeostatic functions. Initially identified in the liver, MIP-3α is expressed in lymphatic tissue, lung tissue, macrophages, dendritic cells, B- and T- lymphocytes, and eosinophilic granulocytes as well as in normal colon, pancreas, prostate, uterine cervix, and skin. To date, MIP-3α is the only known ligand for the CCR6 receptor; it is also chemotactic for CCR6+ cells such as Th17. MIP-3α is implicated in a broad spectrum of disorders, including colorectal cancer and tumor metastasis, rheumatoid arthritis, psoriasis, obesity, and wound healing. Disrupting the MIP-3α and CCR6 interaction may ultimately prove to be a viable therapeutic strategy, as CCR6 deletion resulted in reduced atherosclerotic lesion area and reduced macrophage presence at atherosclerotic plaque sites in models of atherogenesis.The U-PLEX Human MIP-3α Assay provides the components for the quantitative determination of both natural and recombinant human macrophage inflammatory protein 3 alpha (MIP-3α) in serum, plasma, and cell culture supernatants.

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1 plate
5 plates
25 plates
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