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sw sAPPβ is the extracellular protein that is released from the Swedish variant of the amyloid precursor protein (APP) upon cleavage with β-secretase. The Swedish variant contains a two-amino acid substitution (at APP670 and 671), causing it to be more likely to undergo processing by β-secretase than the wild type protein, resulting in higher production of the amyloidogenic Aβ peptides. This kit provides assay-specific components for the quantitative determination of the swedish variant for both natural and recombinant human soluble amyloid precursor protein beta (sw sAPPβ) in cerebrospinal fluid, brain homogenates, and tissue culture supernatants.
Please note: MSD has discontinued this product.
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Specifications
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Documentation
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References
Application(s)
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Alzheimer’s Disease
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Neurobiology/Neurodegeneration
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Analyte(s)
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APP
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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LLOD (Sensitivity)
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0.039 ng/mL
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Dynamic Range
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0.039-1000 ng/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Product Inserts
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Datasheets
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SDS
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Title
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Journal
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Year
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AZ-4217: A high potency BACE inhibitor displaying acute central efficacy in different In vivo models and reduced amyloid deposition in Tg2576 mice.
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Cerebrospinal Flt3 ligand correlates to tau protein levels in primary Sjögren's syndrome.
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High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
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Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers.
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Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxers.
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View All
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