sAPPα/sAPPβ Base Kit

sAPPα and sAPPβ are the extracellular proteins released from the transmembrane amyloid precursor protein (APP) upon cleavage with α-secretase or β-secretase respectively. sAPPβ may be further cleaved by γ-secretase to release Aβ peptides. The sAPPα/sAPPβ Base Kit provides basic components for the quantitative determination of both natural and recombinant soluble amyloid precursor protein alpha (sAPPα) and beta (sAPPβ) in human cerebrospinal fluid, brain homogenates, and tissue culture supernatants. Base Kit provides basic components for the quantitative determination of both natural and recombinant human soluble amyloid precursor protein alpha (sAPPα) in cerebrospinal fluid, brain homogenates, and tissue culture supernatants. Base kits generally include only MSD plates coated with the capture antibody, SULFO-TAG-labeled antibody, and MSD proprietary read buffer. (See product insert for a list of kit components). Base kits are most commonly used for high-throughput screening and assay development.

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