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sAPPα is the extracellular protein that is released from the transmembrane amyloid precursor protein (APP) upon cleavage with α-secretase. Cleavage of APP with α-secretase precludes formation of Aβ peptides, as the cleavage site is within the Aβ sequence. The sAPPα Kit provides assay-specific components for the quantitative determination of both natural and recombinant human soluble amyloid precursor protein alpha (sAPPα) in cerebrospinal fluid, brain homogenates, and tissue culture supernatants.
Please note: MSD has transitioned this product to a status of “made-to-order” with a minimum order size of 25 plates. For an order of the 5-plate pack size, the minimum quantity is 5 packs (25 plates). The 1-plate and 20-plate pack sizes have been discontinued.
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Specifications
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Documentation
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References
Application(s)
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Alzheimer’s Disease
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Neurobiology/Neurodegeneration
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Analyte(s)
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APP
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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LLOD (Sensitivity)
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0.25 ng/mL
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Dynamic Range
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0.25-1000 ng/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Schedule B Code
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3822.19.0000
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Title
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Journal
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Year
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AZ-4217: A high potency BACE inhibitor displaying acute central efficacy in different In vivo models and reduced amyloid deposition in Tg2576 mice.
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Cerebrospinal Flt3 ligand correlates to tau protein levels in primary Sjögren's syndrome.
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High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
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Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers.
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Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxers.
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View All
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