R-PLEX Human MMP-1 Antibody Set Overview The R-PLEX Human MMP-1 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of MMP-1 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Human MMP-1 Antibody Set Features - Measures human MMP-1 in serum, plasma, and urine
- Dynamic range: 1.9 - 10,000 pg/mL
- Median LLOD: 1.9 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Human MMP-1 Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Human MMP-1 Antibody Set Calibration Curve 
MMP-1 Analyte
Description - Matrix metalloproteinase-1 (MMP1, CLG, CLGN, interstitial collagenase) is a member of a family of endopeptidases which are critically important in extracellular matrix remodeling. MMP-1 cleaves collagens of types I, II, III, VII and X. MMP-1 is thought to play an important role in the pathogenesis of rheumatoid arthritis and osteoarthritis by mediating cartilage and bone destruction. MMP-1 has been found to be up-regulated in a variety of cancers and has been suggested to be associated with tumor invasion and metastasis. In addition to collagen, MMP-1 also cleaves a number of non-matrix substrates and probably plays a role in the regulation of cellular behavior.
Disease Research Area - Cancer, Rheumatoid Arthritis, Osteoarthritis
Application Area - Inflammation, Oncology & Cancer
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Recommended Components
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Specifications
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Kit Contents
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References
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Documentation
You will need plates, diluents, and read buffer to run your assay. Please select from the below menu.
R-PLEX Sets are intended to be used with other MSD components such as plates, diluents and MSD Read Buffer. If you don’t already have these items, you can purchase them along with your Antibody Set(s). The “Recommended Components” tab provides helpful suggestions or you can call MSD Customer Service (Phone number) for assistance. R-PLEX Sets can also be used with other antibody sets such as U-PLEX antibody sets (make a link to UPLEX landing page) for multiplex measurements.
Catalog No.
Product Name
Size
R50AA-4
R92TG-3
L45SA-1
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Application(s)
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Immunology/Inflammation
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Oncology & Cancer
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Analyte(s)
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MMP-1
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Species
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Human
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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1.9 - 10,000 pg/mL
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Sample Type
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Serum, Plasma, Urine
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Recombinant standards
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Recombinant protein expressed in mouse myeloma cell line, NS0
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LLOD (Sensitivity)
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1.9 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Gene ID(s)
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4312
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UniProt ID(s)
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P03956
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Assay Diluent(s)
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Diluent 7
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Antibody Diluent(s)
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Diluent 3
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Product Description
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Storage
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Quantity per Kit
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Human MMP-1 Antibody Set (5 Plate Size)
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2-8°C
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1 ea
(5 plate size)
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Human MMP-1 Calibrator
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≤-70°C
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5 vial
(1 vial)
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Product Description
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Storage
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Quantity per Kit
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Human MMP-1 Antibody Set (5 Plate Size)
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2-8°C
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10 ea
(5 plate size)
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Human MMP-1 Calibrator
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≤-70°C
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50 vial
(1 vial)
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Title
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Journal
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Year
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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.
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Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.
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Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis.
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Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?
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Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse.
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Product Inserts
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Product Highlights
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SDS
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Handouts
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Datasheets
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