R-PLEX Human MMP-1 Antibody Set Overview The R-PLEX Human MMP-1 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of MMP-1 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Human MMP-1 Antibody Set Features - Measures human MMP-1 in serum, plasma, and urine
- Dynamic range: 1.9 - 10,000 pg/mL
- Median LLOD: 1.9 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data Calibration curve for the R-PLEX Human MMP-1 Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Human MMP-1 Antibody Set Calibration Curve 
MMP-1 Analyte
Description - Matrix metalloproteinase-1 (MMP1, CLG, CLGN, interstitial collagenase) is a member of a family of endopeptidases which are critically important in extracellular matrix remodeling. MMP-1 cleaves collagens of types I, II, III, VII and X. MMP-1 is thought to play an important role in the pathogenesis of rheumatoid arthritis and osteoarthritis by mediating cartilage and bone destruction. MMP-1 has been found to be up-regulated in a variety of cancers and has been suggested to be associated with tumor invasion and metastasis. In addition to collagen, MMP-1 also cleaves a number of non-matrix substrates and probably plays a role in the regulation of cellular behavior.
Disease Research Area - Cancer, Rheumatoid Arthritis, Osteoarthritis
Application Area - Inflammation, Oncology & Cancer
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Recommended Components
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Specifications
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Kit Contents
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References
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Resources
You will need plates, diluents, and read buffer to run your assay.
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Catalog No.
Product Name
Size
L45SA-1
R50AA-4
R92TG-3
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Application(s)
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Immunology/Inflammation
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Oncology & Cancer
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Analyte(s)
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MMP-1
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Species
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Human
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Dynamic Range
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1.9 - 10,000 pg/mL
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Sample Type
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Serum, Plasma, Urine
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Recombinant standards
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Recombinant protein expressed in mouse myeloma cell line, NS0
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LLOD (Sensitivity)
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1.9 pg/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Gene ID
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4312
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UniProt ID
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P03956
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Assay Diluent(s)
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Diluent 7
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Antibody Diluent(s)
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Diluent 3
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Product Description
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Storage
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Quantity per Kit
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Human MMP-1 Antibody Set (5 Plate Size)
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2-8°C | 1 ea
(5 plate size) |
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Human MMP-1 Calibrator
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≤-70°C | 5 vial
(1 vial) |
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Product Description
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Storage
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Quantity per Kit
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Human MMP-1 Antibody Set (5 Plate Size)
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2-8°C | 10 ea
(5 plate size) |
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Human MMP-1 Calibrator
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≤-70°C | 50 vial
(1 vial) |
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Title
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Journal
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Year
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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.
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Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.
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Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis.
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Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?
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Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse.
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Product Highlights
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SDS
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Handouts
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Datasheets
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