The Mouse IL-17F Antibody is a SULFO-TAG conjugated detection antibody for IL-17F. It is the same detection antibody that is in the V-PLEX Mouse IL-17F Assay. Detection antibody is supplied as a 50X concentrated solution. Mouse IL-17F is a cross-linked homodimer, a prototypical biomarker for Th17 cells, and is closely related to IL-17A. IL-17A can pair with IL-17F to form the IL-17A/F heterodimer of intermediate activity. IL-17F has greater affinity for IL-17RC receptor while IL-17A prefers IL-17RA, so some target-based differentiation is obtained when more than 1 of the possible 3 dimers is present. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL-2, TGF-β, and MCP-1.
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Specifications
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References
Analyte(s)
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IL-17F
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Species
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Mouse
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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2-8 °C
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Title
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Journal
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Year
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Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease-associated psychological morbidity
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