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p53 (protein 53) is a transcription factor and tumor suppressor protein that plays a critical role in cell cycle regulation, progression, and apoptosis. MDM2 (Murine Double Minute 2) is a negative regulator of p53. This kit provides assay-specific components for the quantitative determination of MDM2-p53 complex in tissue culture supernatant.
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Specifications
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Documentation
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References
Application(s)
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Ubiquitinated Proteins
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Intracellular Signaling
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Analyte(s)
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MDM2, p53
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO QuickPlex SQ 120
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MESO QuickPlex SQ 120MM
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MESO SECTOR S 600
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MESO SECTOR S 600MM
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Plate Type
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96-well
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Capture Antibody
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MDM2: Mouse Monoclonal
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Detection Antibody
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p53: Goat Polyclonal
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Kit Model
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Whole Cell Lysate
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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2-8 °C
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Title
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Journal
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Year
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Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.
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Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.
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Multiplexing siRNAs to compress RNAi-based screen size in human cells.
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Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2.
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