Transforming growth factor beta 1 ( TGF-β1) is one of three closely related mammalian members of the large TGF-beta superfamily that shares a characteristic cystine knot structure. TGF-β1 is a highly pleiotropic cytokine that acts as  a cellular switch. It is responsible for regulating processes such as immune function, proliferation, and mesenchymal transition. Human TGF-β1 encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein. TGF-β1 regulates many cellular processes including growth, differentiation, extracellular matrix formation, and immunosuppression. This kit provides the assay-specific components for the quantitative determination of TGF-β1 in human samples.

Please note: MSD has transitioned this product to a status of "made-to-order" with a minimum order size of 25 plates. For an order of the 5-plate pack size, the minimum quantity is 5 packs (25 plates). The 1-plate and 20-plate pack sizes have been discontinued.