The Human KIM-1 Kit provides assay-specific components for the quantitative determination of both natural and recombinant human kidney injury molecule-1 (KIM-1) in urine, serum, and plasma. KIM-1 (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. In addition to acute kidney injury, KIM-1 has been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.
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Specifications
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Kit Contents
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References
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Documentation
Application(s)
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Toxicology
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Analyte(s)
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HAVCR1/KIM-1
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Species
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Human
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Instrument
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MESO QuickPlex SQ 120
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO SECTOR S 600
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Plate Type
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96-well
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Product Description
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Storage
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Quantity per Kit
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Human KIM-1 Calibrator
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≤-70°C
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1 vial (20 μL)
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SULFO-TAG Anti-human KIM-1 Antibody
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2-8°C
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1 vial (75 μL)
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Human KIM-1 Plate
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2-8°C
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1 each (1 each)
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≤-10°C
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1 bottle (25 mL)
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RT
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1 each (50 mL)
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MSD Blocker A
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RT
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1 each (250 mL)
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MSD Phosphate Buffer 5X
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RT
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1 each (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Human KIM-1 Calibrator
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≤-70°C
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5 vial (20 μL)
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SULFO-TAG Anti-human KIM-1 Antibody
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2-8°C
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1 vial (375 μL)
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Human KIM-1 Plate
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2-8°C
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5 each (1 each)
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≤-10°C
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1 bottle (125 mL)
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RT
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1 each (50 mL)
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MSD Blocker A
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RT
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1 each (250 mL)
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MSD Phosphate Buffer 5X
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RT
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1 each (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Human KIM-1 Calibrator
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≤-70°C
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25 vial (20 μL)
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SULFO-TAG Anti-human KIM-1 Antibody
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2-8°C
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5 vial (375 μL)
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Human KIM-1 Plate
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2-8°C
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25 each (1 each)
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≤-10°C
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5 bottle (125 mL)
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RT
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5 each (50 mL)
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MSD Blocker A
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RT
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5 each (250 mL)
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MSD Phosphate Buffer 5X
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RT
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5 each (50 mL)
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Title
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Journal
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Year
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Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.
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Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.
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Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics.
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Assessment of cisplatin-induced kidney injury using an integrated rodent platform.
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Early prediction of polymyxin-induced nephrotoxicity with next generation urinary kidney injury biomarkers.
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View All
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Product Inserts
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Datasheets
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Certificate of analysis
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SDS
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