Apoptosis Whole Cell Lysate Kit


The Apoptosis Whole Cell Lysate Kit provides assay-specific components for the quantitative determination of total p53, phospho-p53 (Ser15), PARP (cleaved), and Caspase-3 (cleaved) in human whole cell lysates. Caspase-3 is initially synthesized as a precursor protein but is activated by proteolytic cleavage of the N-terminus to produce the p20 and p17 cleavage (ASP175) products measured in this kit. PARP becomes inactive following cleavage (ASP214), however, the small cleavage product does retain its DNA-binding capabilities, blocking access to damaged DNA and inhibiting further DNA repair.

Please note: MSD has transitioned this product to a status of “made-to-order” with a minimum order size of 25 plates. For an order of the 5-plate pack size, the minimum quantity is 5 packs (25 plates). The 1-plate and 20-plate pack sizes have been discontinued.

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