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U-PLEX Custom Immuno-Oncology Group 1 (human) Assays

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The U‑PLEX platform makes it easy to create multiplex immunoassays. Using two simple tools - a 10-spot U‑PLEX plate and unique Linkers - you can build multiplex panels for any combination of analytes. The analytes in the U‑PLEX menu are organized into U‑PLEX Groups. Assays within the same U‑PLEX Group have been tested for multiplex compatibility and can be combined in panels with confidence.

The U‑PLEX Immuno-Oncology Group 1 (human) products (Table 1) enable multiplex panels that combine U‑PLEX Immuno-Oncology assays with other content. They are fulfilled with a U‑PLEX plate where some of the spots measure U‑PLEX analytes and some of the spots are left “open.” The “open” spots can be used for custom content such as MSD’s R-PLEX Antibody Sets or antibodies from other sources. Ordering a Custom U‑PLEX assay is simple and can be done online with our U‑PLEX Assay Designer.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	units
4-1BBL/TNFSF9	1.59 - 13,400	pg/mL
APRIL/TNFSF13	7.5 - 45,000	pg/mL
BAFF-R/TNFRSF13C	1.4 - 14,000	pg/mL
BCMA/TNFRSF17	0.13 - 600	pg/mL
BTLA	60.3 - 92,000	pg/mL
CD20	5.7 - 80,000	pg/mL
CD27	0.41 - 3,400	pg/mL
CD276/B7-H3	4.0 - 40,000	pg/mL
CD28	14 - 144,000	pg/mL
CD40/TNFRSF5	0.19 - 1,480	pg/mL
CD40L (soluble)	0.23 - 1,800	pg/mL
CD80/B7-1	0.57 - 6,690	pg/mL
CTACK	1.8 - 4,200	pg/mL
CTLA-4	0.12 - 1,500	pg/mL
E-Cadherin	6.83 - 22,600	pg/mL
E-Selectin	45 - 200,000	pg/mL
ENA-78	0.53 - 3,940	pg/mL
Eotaxin	3.2 - 4,840	pg/mL
Eotaxin-2	3.1 - 6,000	pg/mL
Eotaxin-3	7.3 - 21,400	pg/mL
EPO	1.8 - 20,000	pg/mL
Fas (soluble)	0.22 - 1,600	pg/mL
FasL	0.15 - 1,330	pg/mL
FGF (basic)	2.1 - 1,200	pg/mL
FLT3L	0.49 - 6,000	pg/mL
Fractalkine	100 - 181,000	pg/mL
Galectin-9	0.41 - 5,500	pg/mL
G-CSF	1.6 - 20,400	pg/mL
GITR/TNFRSF18	0.18 - 1,300	pg/mL
GITRL/TNFSF18	0.09 - 1,000	pg/mL
GM-CSF	0.12 - 9,440	pg/mL
gp130 (soluble)	5.8 - 188,000	pg/mL
Granzyme A	0.49 - 3,700	pg/mL
Granzyme B	0.10 - 750	pg/mL
GRO-α	0.25 - 2,500	pg/mL
HAVCR1/KIM-1	0.25 - 3,000	pg/mL
HAVCR2/TIM-3	2.1 - 9,500	pg/mL
HVEM/TNFRSF14	0.53 - 5,000	pg/mL
I-309	6.8 - 3,000	pg/mL
ICOS	1.8 - 9,000	pg/mL
ICOS-L/B7-H2	0.98 - 12,000	pg/mL
IDO-1	3.5 - 16,800	pg/mL
IFN-α2a	4.0 - 42,400	pg/mL
IFN-β	1.2 - 9,530	pg/mL
IFN-γ	1.7 - 17,000	pg/mL
IL-1α	0.98 - 5,080	pg/mL
IL-1β	0.15 - 3,820	pg/mL
IL-1RA	1.7 - 5,000	pg/mL
IL-2	0.70 - 1,940	pg/mL
IL-2Rα	10 - 55,000	pg/mL
IL-3	11 - 16,000	pg/mL
IL-4	0.08 - 2,060	pg/mL
IL-5	0.24 - 4,040	pg/mL
IL-6	0.33 - 1,980	pg/mL
IL-7	1.5 - 7,040	pg/mL
IL-8	0.15 - 2,210	pg/mL
IL-9	0.14 - 1,500	pg/mL
IL-10	0.14 - 3,720	pg/mL
IL-12/IL-23p40	2.8 - 21,000	pg/mL
IL-12p70	0.69 - 5,320	pg/mL
IL-13	3.1 - 1,920	pg/mL
IL-15	0.82 - 3,030	pg/mL
IL-16	6.6 - 21,500	pg/mL
IL-17A	2.6 - 23,400	pg/mL
IL-17A/F	1.8 - 18,400	pg/mL
IL-17C	2.2 - 20,000	pg/mL

Analyte	LLOD - ULOD	units
IL-17D	4.8 - 40,000	pg/mL
IL-17E/IL-25	0.58 - 9,240	pg/mL
IL-17F	160 - 112,000	pg/mL
IL-18	2.5 - 42,000	pg/mL
IL-21	1.2 - 12,600	pg/mL
IL-22	0.13 - 3,420	pg/mL
IL-23	1.4 - 21,600	pg/mL
IL-27	9.6 - 50,600	pg/mL
IL-29/IFN-λ1	1.2 - 11,800	pg/mL
IL-31	7.3 - 11,100	pg/mL
IL-33	0.59 - 10,300	pg/mL
IP-10	0.49 - 6,000	pg/mL
I-TAC	1.5 - 5,080	pg/mL
LAG3	6.8 - 36,000	pg/mL
LIGHT/TNFSF14	0.58 - 12,000	pg/mL
MCP-1	0.74 - 6,560	pg/mL
MCP-2	0.11 - 2,000	pg/mL
MCP-4	7.5 - 3,800	pg/mL
M-CSF	0.29 - 2,000	pg/mL
MDC	8.4 - 20,100	pg/mL
MIF	4.3 - 27,000	pg/mL
MIG	0.73 - 4,000	pg/mL
MIP-1α	7.7 - 4,200	pg/mL
MIP-1β	1.5 - 1,640	pg/mL
MIP-5	0.34 - 30,000	pg/mL
MMP-1	1.4 - 15,000	pg/mL
MMP-2	10 - 25,000	pg/mL
MMP-7	1.8 - 9,000	pg/mL
MMP-8 (total)	0.83 - 7,310	pg/mL
MMP-9 (total)	0.88 - 15,000	pg/mL
MMP-10 (total)	0.37 - 2,370	pg/mL
Nectin-4	1.6 - 10,000	pg/mL
OX40/TNFRSF4	0.26 - 1,800	pg/mL
PD1 (epitope 1)	0.25 - 2,200	pg/mL
PD1 (epitope 2)	0.11 - 2,200	pg/mL
PDGF-B	0.088 - 1,050	pg/mL
PD-L1 (epitope 1)	0.09 - 1,100	pg/mL
PD-L1 (epitope 2)	0.55 - 1,500	pg/mL
PD-L2	3.9 - 41,000	pg/mL
Pentraxin 3	12 - 40,000	pg/mL
Perforin	1.9 - 20,000	pg/mL
PlGF	0.19 - 1,200	pg/mL
proMMP-8	0.89 - 7,310	pg/mL
proMMP-9	1.4 - 15,000	pg/mL
proMMP-10	0.38 - 2,370	pg/mL
P-Selectin	11 - 40,000	pg/mL
RAGE (soluble)	0.26 - 2,000	pg/mL
RANKL/TNFSF11	1.8 - 4,000	pg/mL
RANTES	0.41 - 1,500	pg/mL
S100A12	0.10 - 750	pg/mL
TACI/TNFRSF13	12.1 - 59,300	pg/mL
Tie-2	2.9 - 29,000	pg/mL
TIGIT	0.36 - 3,500	pg/mL
TLR1	4.4 - 37,000	pg/mL
TNF-α	0.51 - 3,650	pg/mL
TNF-β	0.47 - 4,320	pg/mL
TNF-RI	0.15 - 1,000	pg/mL
TNF-RII	1.6 - 7,000	pg/mL
TPO	19 - 40,400	pg/mL
TRAIL	0.66 - 10,000	pg/mL
TSLP	0.20 - 10,100	pg/mL
VEGF-A	2.0 - 4,920	pg/mL
VEGF-D	0.30 - 1,500	pg/mL
VEGFR-1/Flt-1	2.7 - 15,000	pg/mL
YKL-40	0.39 - 5,000	pg/mL

Specifications
Documentation
References

Application(s)		Immunology/Inflammation
Analyte(s)		4-1BBL/TNFSF9, APRIL/TNFSF13, BAFF-R/TNFRSF13C, BCMA/TNFRSF17, BTLA, CD20, CD27, CD28, CD40/TNFRSF5, CD40L (soluble), CD80/B7-1, CD276/B7-H3, CTACK, CTLA-4, E-Cadherin, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, E-Selectin, Fas (soluble), FasL, FGF (basic), FLT3L, Fractalkine, Galectin-9, G-CSF, GITR/TNFRSF18, GITRL/TNFSF18, GM-CSF, gp130 (soluble), Granzyme A, Granzyme B, GRO-α, HAVCR1/KIM-1, HAVCR2/TIM-3, HVEM/TNFRSF14, I-309, ICOS, ICOS-L/B7-H2, IDO-1, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, IP-10, I-TAC, LAG3, LIGHT/TNFSF14, MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIG, MIP-1α, MIP-1β, MIP-5, MMP-1, MMP-2, MMP-7, MMP-8 (total), MMP-9 (total), MMP-10 (total), Nectin-4, OX40/TNFRSF4, PD1 (epitope 1), PD1 (epitope 2), PDGF-B, PD-L1 (epitope 1), PD-L1 (epitope 2), PD-L2, Pentraxin 3, Perforin, PlGF, proMMP-8, proMMP-9, proMMP-10, P-Selectin, RAGE (soluble), RANTES, S100A12, TACI/TNFRSF13B, Tie-2, TIGIT, TLR1, TNF-α, TNF-β, TNF-RI, TNF-RII, TPO, TRAIL, TSLP, VEGF-A, VEGF-D, VEGFR-1/Flt-1, YKL-40
Species		Human
Plate Type		96-well
U-PLEX Group Compatibility		Immuno-Oncology Group 1
Instrument(s)		MESO SECTOR S 600MM , MESO QuickPlex SQ 120MM , MESO QuickPlex Q 60MM , MESO SECTOR S 600 , MESO QuickPlex SQ 120 , SECTOR Imager 6000 , SECTOR Imager 2400
Sample Type		Plasma, Serum
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

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K151AEM

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1-240-314-2795

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Scientific/Technical Support
1-240-314-2798

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Product Inserts		U-PLEX I-O Group 1 (human) Multiplex Insert
Datasheets		U-PLEX Human 4-1BBL/TNFSF9 U-PLEX Human BAFF-R U-PLEX Human BCMA U-PLEX Human BTLA U-PLEX Human CD20 U-PLEX Human CD27 U-PLEX Human CD276/B7-H3 View More
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8 Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101 Diluent 57, Diluent 58, and Diluent 59 MSD Calibrators and Controls MSD GOLD Read Buffer B U-PLEX Linker Set
Scientific Posters		Expansion of Human Immuno-Oncology Assays on a Multiplexed Electrochemiluminescence Platform

Title	Journal	Year
A phase 1 study of prophylactic anakinra to mitigate ICANS in patients with large B-cell lymphoma Paolo Strati, Andrew Jallouk, Qing Deng, Xubin Li, Lei Feng, Ryan Sun, Sherry Adkins, Swapna Johncy, Taylor Cain, Raphael E. Steiner, Sairah Ahmed, Dai Chihara, Luis E. Fayad, Swaminathan P. Iyer, Sandra Horowitz, Loretta J. Nastoupil, Ranjit Nair, Ahmed Hassan, Taher E. Daoud, Misha Hawkins, Maria A. Rodriguez, Elizabeth J. Shpall, Jeremy L. Ramdial, Partow Kebriaei, David S. Hong, Jason R. Westin, Sattva S. Neelapu, Michael R. Green	Blood Advances	2023
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms and Matthew Stevenson	Frontiers in Toxicology	2023
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén	JAMA Network Open	2022
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations Bing Sun, Norina Tang, Michael J. Peluso, Nikita S. Iyer, Leonel Torres, Joanna L. Donatelli, Sadie E. Munter, Christopher C. Nixon, Rachel L. Rutishauser, Isabel Rodriguez-Barraquer, Bryan Greenhouse, John D. Kelly, Jeffrey N. Martin, Steven G. Deeks, Timothy J. Henrich, and Lynn Pulliam	Cells	2021
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
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U-PLEX Custom Immuno-Oncology Group 1 (human) Assays

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K151AEM

S 600

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Q 60

Customize your assay with U-PLEX Assay Designer Tool

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