sw sAPPβ is the extracellular protein that is released from the Swedish variant of the amyloid precursor protein (APP) upon cleavage with β-secretase. The Swedish variant contains a two-amino acid substitution (at APP670 and 671), causing it to be more likely to undergo processing by β-secretase than the wild type protein, resulting in higher production of the amyloidogenic Aβ peptides. This kit provides assay-specific components for the quantitative determination of the swedish variant for both natural and recombinant human soluble amyloid precursor protein beta (sw sAPPβ) in cerebrospinal fluid, brain homogenates, and tissue culture supernatants.

Please note: MSD has discontinued this product.