Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease.

Björkqvist M, Ohlsson M, Minthon L, Hansson O.
Journal   PLoS One.
Species  
Analytes Measured   M-CSF
Matrix Tested   Plasma
Year   2012
Volume   7
Page Numbers   e29868
Application   Alzheimers , Cytokines and Chemokines
Abstract
There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.

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