VEGFR-2/KDR

Vascular endothelial growth factor receptor-2 (VEGFR-2), also known as KDR (human) and Flk1 (mouse), is an endothelial cell receptor tyrosine kinase with seven extracellular Ig-like domains. These domains contain a ligand binding site, a single transmembrane domain, and an intracellular region containing the tyrosine kinase domain split by a non-catalytic kinase insert domain. Upon binding its ligand, VEGF, VEGFR-2 undergoes dimerization that in turn activates its tyrosine kinase activity, resulting in the auto-phosphorylation of several tyrosines (Tyr951/996 and Tyr1054/1059). Ligand-independent activation of VEGFR-2 and the subsequent activation of PI-3K/ Akt and eNOS has been observed with fluid shear stress in blood vessels, thereby leading to the production of NO and regulation of vascular homeostasis. VEGFR-2 is a critical mediator of the angiogenic functions of VEGF, and is an attractive target for anti-angiogenic drugs relating to disease states such as cancer, macular degeneration, and diabetic retinopathy.

 

VEGFR-2/KDR Singleplex Products

Our VEGFR-2/KDR immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of VEGFR-2/KDR. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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VEGFR-2/KDR Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-VEGFR2 -
  • VEGFR-2 (pTyr1175) - Mouse
  • VEGFR-2 (total) - Human
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