VASP

Vasodilator-stimulated phosphoprotein (VASP) is an adaptor protein which belongs to the Ena/VASP family of proteins and contains an EVH1 domain, EVH2 domain, and a proline rich region which binds to SH3 and WW domain containing proteins, and functions in cell motility, axon guidance, cell adhesion, endocytosis, and intracellular pathogen motility. VASP binds to the growing barbed ends of actin filaments preventing capping proteins from binding and terminating actin elongation. VASP is phosphorylated at serine 157 (PKA phosphorylation site), serine 239 (PKG phosphorylation site), and threonine 278. Phosphorylation is believed to inhibit VASP interactions with actin and decrease its anti-capping activity. Due to its involvement in actin elongation, cell motility, and the signal transduction cascades, VASP plays a role in a variety of normal processes as well as in many diseases, such as: cancer, arteriosclerosis, nephritis, thrombosis, and cardiomyopathy.

 

VASP Singleplex Products

Our VASP immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of VASP. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-VASP (Ser157) -
  • Phospho-VASP (Ser239) -
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