Troponin ITC Complex

Troponin is a heterotrimer that regulates muscle contraction in skeletal and cardiac muscle (but not in smooth muscle). Troponin acts with intracellular calcium to control the interaction of actin and myosin filaments in striated muscle fibers. Though they perform similar functions, cardiac and skeletal troponins differ in sequence and can be differentiated in immunoassays. Troponin complex consists of three different subunits – troponin T (TnT), troponin I (TnI) and troponin C (TnC) as described below: 1. Troponin T is the subunit that interacts with tropomyosin to form the troponin-tropomyosin complex. 2. Troponin I is an inhibitory subunit that prevents muscle contraction in the absence of calcium. It is responsible for the binding of the troponin-tropomyosin complex to actin. Troponin I exists in three isoforms: slow-twitch (striated) skeletal muscle, fast-twitch (striated) skeletal muscle, and cardiac muscle. 3. Troponin C binds calcium, producing a conformational change in troponin I and activating the troponin-tropomyosin complex.

 

Troponin ITC Complex Singleplex Products

Our Troponin ITC Complex immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Troponin ITC Complex. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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