Tau

The human tau protein family consists of six isoforms which are alternatively spliced from the MAPT gene. Tau is expressed primarily in neuronal cells where it localizes to the axon and impacts both cytoskeletal structure and cell signaling. Tau has emerged as a putative therapeutic target for many neurodegenerative disorders, including Alzheimer’s disease, frontotemporal dementia, Pick’s disease, progressive supranuclear palsy, and corticobasal degeneration. A key characteristic of these tauopathies is the presence of intracellular neurofibrillary tangles made up predominantly of hyperphosphorylated forms of the protein. Tau and Aβ42 have been identified as core biomarkers of Alzheimer’s disease. Their levels in cerebrospinal fluid (CSF) reproducibly distinguished normal and Alzheimer’s patients, and the combination may be useful in identifying patients with mild cognitive impairment (MCI). Studies aimed at evaluating the association between Alzheimer-type pathologic changes in the brain and antemortem CSF levels of Aβ42 and tau protein indicated that levels of both proteins correlated with the presence of neurofibrillary tangles and Aβ in the brain. CSF total tau and Aβ42 levels are effective markers for discriminating incipient Alzheimer’s from age-related memory impairment, depression, and some secondary dementias.

 

Tau Singleplex Products

Our Tau immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Tau. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Tau Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-Tau (Thr231) -
  • Tau (pSer202) - Human
  • Tau (pSer262) - Mouse
  • Tau (pThr181) - Human
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