STAT5a/b

Signal Transducer and Activator of Transcription 5a and 5b (STAT 5a and 5b) are members of the STAT family of transcription factors, part of the Jak/STAT signal transduction pathway, and are approximately 90% identical at the amino acid level. When inactive, STATs are cytoplasmic; upon ligand binding and activation of a cytokine receptor, the receptor binds to a member of the Jak family. The receptor is phosphorylated, recruits a member of the STAT family, which is also phosphorylated, dimerizes, and is then transported into the nucleus where it can act as a transcription factor. STAT5a,b are involved in many different types of cancer (such as breast and prostate), inflammatory responses, and allergic reactions. STAT5s also play a role in preventing apoptosis in certain cell types and diseases, based upon their role as transcription factors and the genes they regulate.

 

STAT5a/b Singleplex Products

Our STAT5a/b immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of STAT5a/b. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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STAT5a/b Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-STAT5a/b (Tyr694) -
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