STAT4

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor that transduces Interleukin-12, Interleukin-23, and type 1 interferon cytokine signals in T-cells and monocytes. Following exposure to cytokines, the cytokine receptor-associated Janus kinases (JAK) phosphorylate tyrosine residues present on cytoplasmic STAT4 proteins. STAT4 phosphorylation at Tyrosine residue 693 allows homodimerization via src homology 2 domains. Functional STAT4 dimers translocate into the nucleus and activate cytokine responsive gene transcription, leading to Th1 cell differentiation, monocyte activation, and interferon-gamma production. STAT4 contributes to autoimmune disorder pathogenesis and anti-viral immune responses.

 

STAT4 Singleplex Products

Our STAT4 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of STAT4. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-STAT4 (Tyr693) -
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