STAT3

STAT3 is one of a family of cytoplasmic transcription factors activated by cytokines, growth factors, and hormones. Phosphorylation of STAT3 on tyrosine 705 results in its activation and subsequent dimerization, nuclear translocation, and DNA binding. In response to cellular stimulation by cytokines, STAT3 phosphorylation is mediated through the JAK family of receptor associated tyrosine kinases, most notably JAK1. Growth factor receptors with intrinsic tyrosine kinase activities may phosphorylate STAT3 directly, and the non-receptor tyorsine kinase SRC has been shown to phophorylate STAT3 as well. Activated STAT3 has been shown to play a critical role in cellular processes including proliferation, tissue-dependent cell survival of apoptosis, and embryonic development and organogenesis. Constitutively activated STAT3 has been observed in breast, skin, prostate, lung, and breast cancers.

 

STAT3 Singleplex Products

Our STAT3 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of STAT3. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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STAT3 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-STAT3 (Thr705) -
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