Resistin

Resistin is a peptide hormone, derived from adipocytes and immune cells. In mice, administration of anti-resistin antibody improves blood sugar and insulin action. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. In addition, serum resistin levels are elevated in two different genetic models (ob/ob and db/db) as in a diet-induced model of diabetes. Thus, resistin might link obesity with insulin resistance and diabetes in murine models. Expression of resistin in human adipocytes is very low compared with that seen in rodents and does not differ between normal, insulin-resistant and T2DM individuals. In humans, resistin is expressed in inflammatory cells, leukocytes, and macrophages and has the potency of inducing production of interleukin-6 and tumor necrosis factor-alpha. Similarly, resistin is accumulated in inflamed joints of patients with RA and has the capacity to induce arthritis in mice.

 

Resistin Singleplex Products

Our Resistin immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Resistin. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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