RBP4

Retinol-binding protein 4 (RBP4) is a member of the lipocalin superfamily that transports Vitamin A (retinol) from liver stores to peripheral tissues via serum. The RBP4-retinol complex interacts with transthyretin (TTR) and prevents it from being filtered by the kidney. The C-terminal, processed forms of RBP4 do not bind TTR; they are excreted into the urine and, during renal failure, they accumulate in the serum. RBP4 also acts as an adipokine and has been linked to the development of obesity, type 2 Diabetes and insulin resistance. The protein is secreted by adipocytes and hepatocytes and promotes hyperglycemia through downregulation of the glucose transporter type 4. Elevated RBP4 in urine and serum often mirrors the onset of cardiovascular complications and acute renal dysfunction associated with these diseases. Thus, measurement of urine, serum, or plasma RBP4 is a useful means for the understanding of various metabolic disorders.

 

RBP4 Singleplex Products

Our RBP4 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of RBP4. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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