RAGE (soluble)

Soluble Receptor of Advanced Glycation End-products (RAGE [soluble], AGER, sRAGE, SCARJ1) is a member of the immunoglobulin superfamily of cell surface molecules. RAGE is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily, and advanced glycation end products. RAGE mediates interactions of non-enzymatic glycosylated proteins which accumulate in vascular tissue during aging and at an increasing rate in diabetes. Its expression decreases throughout development in several types of cells, including neurons, endothelium, pericytes, smooth muscle cells, mononuclear phagocytes, cardiac myocytes, hepatocytes, renal glomerular epithelial cells, and Muller and bipolar ganglion cells of the retina. Expression of RAGE remains at high levels in the lung alveolar epithelial cells in adult tissues. The soluble version of RAGE is produced from two distinct pathways: specific secretion and enzymatic cleavage of the extracellular domain of a membrane-bound RAGE.

 

RAGE (soluble) Singleplex Products

Our RAGE (soluble) immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of RAGE (soluble). MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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